Riley is uprooted from her Midwest life when her father starts a new job in San Francisco. Riley is guided by her emotions—Joy, Fear, Anger, Disgust, and Sadness. The emotions live in Headquarters, the control center inside RileyÂ's mind, where they help advise her through everyday life. As Riley and her emotions struggle to adjust to a new life in San Francisco, turmoil ensues in Headquarters. Although Joy, RileyÂ's main and most important emotion, tries to keep things positive, the emotions conflict on how best to navigate a new city, house and school.