Based on William Brinkley's popular novel, The Last Ship chronicles a global catastrophe that nearly decimates the world's population. Because of its positioning, the Navy destroyer U.S.S. Nathan James avoided falling victim to the devastating tragedy. But now, Captain Tom Chandler (Eric Dane) and his crew must confront the reality of their new existence in a world where they may be among the few remaining survivors. Following the epic second season cliffhanger, the highly anticipated third season finds the crew of the Nathan James shifting their attention to Asia after President Michener hears rumblings that the Chinese leader, President Peng, has been hoarding the "Scott cure" instead of distributing it to the people in the region. Michener sends Chandler to a global summit to investigate this allegation, as well as rumors of a possible mutation of the original virus that has caused a fresh outbreak in Japan. If the mutation has occurred, and Asia has not been protected, the consequences for the world are dire. With Rachel Scott shot in the season two finale, and her fate as yet unknown, hope is in short supply.